Preventive effect of pomegranate juice on ESWL-related renal damage in patients with kidney stones

Objective: We aimed to show whether the antioxidant properties of pomegranate juice (PJ) a protective effect against renal damage associated with oxidative stress caused by Extracorporeal Shock Wave Lithotripsy (ESWL) in patients who have undergone ESWL for kidney stones. Material and Methods: Ninety were undergo stones included study divided into 3 groups 30 each ESWL. Group 1 (control group) received only treatment. 2 (study recommended take ml/kg/day mixture orally days before (placebo mg/kg/day water All ESWL-treated 2000 2500 shock waves at 18 24 order measure lipid peroxidation markers showing DNA lesion tubular after ESWL, Results: There was statistically significant mean increase 52.39± 10.49 8-Hydroxy deoxyguanosine (8-OHdG) levels treatment compared pre-treatment (p<0.01). 13.16±7.71 33.24±12.82 Groups 3, respectively (p<0.01; p<0.01, respectively) 19.20±5.21 N-acetyl-beta-D-glucosaminidase (NAG) 3.44±5.21 13.07±5.50 respectively). Conclusion: Our concluded that has effects ESWL-related damage. Keywords: Antioxidant, stones, lithotripsy, juice.